Diagnosis and treatment of multiple basal cell carcinoma: a case report and literature review
DOI:
https://doi.org/10.32782/2415-8127.2026.73.2Keywords:
skin cancer, basal cell carcinoma, dermatoscopy, microsurgeryAbstract
Management of multiple BCC requires a comprehensive approach that includes early diagnosis, knowledge of current treatment methods, and individualized strategy selection. Future research prospects lie in three key areas: improving existing treatments, reducing the toxicity of systemic therapy, and searching for new biomarkers for more accurate patient classification.
Aim of the work is to analyze current approaches to the management of patients with multiple basal cell carcinoma based on the description of clinical cases and a review of the current literature.
A scientific search was conducted for the period from 2010 to 2025 using the primary search strategy "multiple basal cell skin cancer", "Gorlin-Goltz syndrome" and the combination AND/OR in the scientometric databases MEDLINE (PubMed), Scopus, and Web of Science.
Current studies indicate that basal cell carcinoma is a clinically complex problem and requires the involvement of a multidisciplinary team. Our clinical cases illustrate two different scenarios: sporadic multiple BCC on the background of chronic sun damage to the skin in an elderly patient and hereditary Gorlin syndrome. Surgical excision, in particular Mohs microsurgery, demonstrated better tumor control rates for basal cell carcinoma compared to radiotherapy. The results obtained emphasize the higher effectiveness of surgery in achieving complete tumor removal and minimizing recurrence.
Multiple basal cell carcinoma is an important clinical problem, for the diagnosis and treatment of which it is necessary to involve a multidisciplinary team and a personalized approach. Patients with multiple basal cell carcinomas require lifelong surveillance and strict sun protection measures to prevent new lesions.
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