Non-invasive diagnostic of liver damage in patients with non-alcoholic fatty liver disease and diabetes mellitus type 2

Abstract

Introduction: Science is actively searching for new non-invasive and high-informative methods, that can help to reveal the stage of liver damage and also its functional state, especially in patients with combined pathology. The aim of the research is: to assess the effectiveness of different non-invasive diagnostic methods for revealing the stage of liver damage in patients with non-alcoholic fatty liver disease (NAFLD) and diabetes mellitus (DM) type 2. Materials and methods: General clinical examination was performed to 64 patients with NAFLD and DM type 2. The extent of liver damage was figured out with the help of surrogate markers of liver fibrosis and online calculator: NAFLD fibrosis score (NFS), Fibrosis 4 calculator (FIB-4), fibrotest and commercial test «FibroMax». Liver damage was also measured with elastometry and metacetin 13C-breath test. The results of the research: NFS та FIB-4 only showed us the presence of liver fibrosis. At the same time, fibrotest revealed F2 stage of liver fibrosis (according to METAVIR). The results of FibroMax showed us also the presence of steatohepatitis in examined patients (SteatoTest – 0.60±0.11 - р<0.01; NashTest – 0.73±0.12 – р<0.01). The stage of liver damage was appropriate to F2 stage (according to METAVIR), level of activity was mini-mal (А1 – 0.38±0.14). The results of elastometry confirmed F2 stage of liver fibrosis according to METAVIR (6.21±0.54 kPa). Conclusions: Non-invasive diagnostic methods such as elastometry, online fibrotest based on surrogate markers of liver fibrosis and commercial test FibroMax are effective and informative for revealing the stage of fibrosis in current patients.