The use of cell technologies in the complex treatment of patients with venoustrophic ulcers

Abstract

The high prevalence of the disease in the population, the need to search for new and improve existing methods of complex treatment of lower extremity trophicul cers made it a topical issue of modern medicine. Due to the enormous biologicalvalue of cord blood, it is regarded as one of the main stemcellsources. The aim of this study was to evaluate and compare the results of treatment of patients with chronic venousin sufficiency of the lower extremities, complicated by trophiculcer, resistant to standard therapy after and without cord bloodstemcell transplantation. Patients who had a history of surgical intervention for the correction of venous hypertension had a nulceratived efect of at least 2 years on the background of basic therapy under epidural anesthesia punctually under the ulcercell suspension was injected. The healingrate index was determined by Popova's formula in the modification of Girka E.I., Kravtsova E.A. The healingprocess in the patients of the main group began on the first day after transplantation with the reduction of pericellulare demaand in flammatory hyperemia of the soft tissues around the ulcer, almost no "minustissue" was observed, granulation initially actively built up, raising the bottom of the ulcer dermal level, and the nthehealing process was mainly due to marginal epithelialization. The healingindex rate of the ulcer defectin the main and control groups varied throughout the observation period and in patients after cord blood stemcell transplantation was 1.5-2 times higher than in patients treated with standard conservative therapy. Cord blood cell transplantation leads to activation of the body's own regenerative reserves and influences the various pathogens chains of the development of venous trophic ulcers and acceleratesit’s healing.