The update approach to treatment of deep vein thrombosis
DOI:
https://doi.org/10.24144/2415-8127.2020.61.14-19Keywords:
deep vein thrombosis, anticoagulation therapy, diagnosis.Abstract
An analysis of the diagnosis and treatment of 98 patients with deep vein thrombosis was performed.Depending on the scheme of anticoagulant therapy, patients were divided into three groups: the first group 32 – received warfarin, the second group 34 – rivaroxaban, and the third 32 – dabigatran etexilate. All patients to verify the diagnosis and monitoring of a therapy performed ultrasonographic study evaluated thrombogenic properties of peripheral blood (level, time, speed aggregation, von Willebrand factor) coagulation and anticoagulant blood system (antithrombin, protein C, the level of D-dimer). A specialized CIVIQ-1 questionnaire was used to assess patients’ quality of life. The Villalta scale was used to establish both the diagnosis and severity of PTS.Based on the results of the study, it is concluded that the treatment of patients with deep vein thrombosis requires individualized approachesto defining the scheme and timing of anticoagulation therapy.
References
Jeraj L, Jezovnik MK, Poredos P (2017) Rivaroxaban versus warfarin in the prevention of postthrombotic syndrome. Thromb Res 157:46–48.
Prandoni P, Ageno W, Mumoli M et al (2017) Recanalization rate in patients with proximal vein thrombosis treated with the direct oral anticoagulants. Thromb Res 153:97–100.
Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, et al. Antithrombotic therapy for VTE disease: CHEST Guideline and Expert Panel Report. Chest. 2016;149:315-52.
Kearon C, Ageno W, Cannegieter SC, Cosmi B, Geersing GJ, Kyrle PA, et al. Categorization of patients as having provoked or unprovoked venous thromboembolism: Guidance from the SSC of ISTH. J Thromb Haemost. 2016;14:1480-3.
Young AM. Marshall A. Thirlwall J. Chapman O. Lokare A. Hill C. et al. Comparison of an oral factor Xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism: results of a randomized trial (SELECT-D). J Clin Oncol. 2018;36:2017-23.
Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Turpie AG, Bormanis J, Weitz J, Chamberlain M, Bowie D, et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med. 1998;129:997–1005. doi: 10.7326/0003-4819-129-12-199812150-00002.