Clinical features of pancreatic lesions in patients with diabetes mellitus and chronic pancreatitis

Abstract

Introduction. Diabetes mellitus (DM) is the most dangerous challenge for humanity in the 21st century. Patholo-gies of the pancreas, including chronic pancreatitis (CP), the rate of distribution, the percentage of patients who are temporarily and permanently lost their capacity to work, without exaggeration can also be attributed to major medical and social problems of modern world. The purpose of the study – to determine the clinical features of pancreatic lesions in chronic pancreatitis in pa-tients with diabetes mellitus types 1 and 2. Materials and methods of research. 84 patients with diabetes and CP were examined. The patients were divided into 2 groups: group I included 40 patients with type 1 diabetes mellitus, and group II comprised 44 patients with type 2 diabetes. All surveyed patients underwent general clinical, anthropometric, instrumental and laboratory methods of investigation. Results and Discussion. All patients with diabetes clinically have changes in the digestive system. In patients of group I were predominant manifestations of intestinal dyspepsia and in patients of group II these were – complaints characteristic of biliary dyspepsia. In 57.5% of patients of I and 63.6% of patients of group II the pain was defined. In the group of patients with type 1 diabetes, patients with normal body weight and body weight deficiency were predominant (45.0% and 35.0%, respectively, p <0.01), whereas among patients with type 2 diabetes, persons with obesity first grade and overweight (38.6% (p <0.01) and 31.5% (p <0.05), respectively). Conclusions. 1. Clinical defeat of the pancreas in patients with type 1 diabetes and CP is manifested by signs of intestinal dyspepsia (diarrhea, polyfecal disease, flatulence) and severe spastic pain of periodic nature. 2. In patients with type 2 diabetes and CP, pancreatic lesions in the vast majority of cases manifest dyspeptic disorders (nausea, vomiting, bitterness in the mouth) at the background of constant, aching pain in the upper abdomen. 3. Patients with normal weight and deficiency of body weight predominate in the assessment of fatness in the group of patients with type 1 diabetes and CP, while among the patients with type 2 diabetes and CP there are persons with obesity first grade and overweight.