Lyme disease – clinical course features (literature overview)
DOI:
https://doi.org/10.32782/2415-8127.2025.71.8Keywords:
ticks, Lyme disease, specific prophylaxisAbstract
Relevance. Infectious diseases have always been and remain relevant throughout the history of mankind. In particular, in recent years, the number of cases of zoonotic anthropogenic diseases, the pathogens of which are transmitted mainly through tick bites, has increased. The epidemiological situation with regard to such infections as Lyme borreliosis and tick-borne encephalitis changes every year. With the growing popularity of tourism, these infections are becoming a problem outside of endemic regions. An increasing number of cases of these diseases unrelated to occupational risk factors are being registered, which attracts attention and requires a review of attitudes towards these diseases, deeper research and study of their pathogenesis, clinical manifestations, diagnostic and treatment methods, as well as the search for and application of the most effective prevention methods.The main goal of the study: is to depict both typical and atypical clinical features of Lyme’s disease, while briefly mentioning its’ preven- tion measures, diagnosis and treatment, using a variety of recently published literature.Materials and methods: the article uses the bibliographic method and is a review of existing works on PubMed and Google Scholar, as well as other on-topic literature.Research results and their discussion: аnalysed information from modern foreign and domestic sources. The data obtained indicate the relevance of the chosen topic. Due to the fact that in Ukraine in recent years less attention has been paid to pest control, due to insufficient fund- ing for this sector and attempts to eliminate the sanitary and epidemiological link, the amount of insects carrying the pathogens of the above diseases is growing year by year. City parks and some courtyards adjacent to houses are dangerous to visit. This problem becomes especially acute from May to October every year. An analysis of foreign sources has shown a significant spread of Lyme borreliosis in economically developed countries, namely Switzerland, Italy, Germany, and the Czech Republic. Of course, this is due to the complexity of disinfestation and the lack of government programmes for insect extermination.Conclusions: So, the imperfection of the preventive link, namely sanitary and educational measures, the severity of these diseases, com- plications both after the diseases and after their treatment. All this prompts us to look for ways to solve these problems in order to prevent the emergence of new cases and improve treatment measures.
References
Pulkkinen LI, Barrass SV, Domanska A, Överby AK, Anastasina M, Butcher SJ. Molecular organisation of tick-borne enceph- alitis virus. Viruses. 2022;14(4):792.
Pulkkinen LI, Butcher SJ, Anastasina M. Tick-borne encephalitis virus: a structural view. Viruses. 2018;10(7):350.
Golovljova I, Vene S, Sjölander KB, Vasilenko V, Plyusnin A, Lundkvist Å. Characterization of tick‐borne encephalitis virus from Estonia. J Med Virol. 2004;74(4):580-588.
Riccò M. Epidemiology of Tick-borne encephalitis in North-Eastern Italy (2017-2020): international insights from national notification reports. Acta Biomed. 2021;92(5).
Kaiser R. Incidence and occurrence of tick-borne encephalitis and neuroborreliosis in Germany. Ticks Tick Borne Dis. 2022;13(2):101867.
Yoshii K. Epidemiology and pathological mechanisms of tick-borne encephalitis. J Vet Med Sci. 2019;18-0373.
Du Y, Mi Z, Xie Y, Lu D, Zheng H, Sun H, et al. Insights into the molecular basis of tick-borne encephalitis from multiplat- form metabolomics. PLoS Negl Trop Dis. 2021;15(3)
Vandekerckhove O, De Buck E, Van Wijngaerden E. Lyme disease in Western Europe: an emerging problem? A systematic review. Acta Clin Belg. 2021;76(3):244-252.
Stevenson B, Krusenstjerna AC, Castro-Padovani TN, Savage CR, Jutras BL, Saylor TC. The Consistent Tick-Vertebrate Infectious Cycle of the Lyme Disease Spirochete Enables Borrelia burgdorferi To Control Protein Expression by Monitoring Its Physiological Status. J Bacteriol. 2021;e00606-21.
Kohlmaier B, Schweintzger NA, Sagmeister MG, Švendová V, Kohlfürst DS, Sonnleitner A, et al. Clinical characteristics of patients with tick-borne encephalitis (TBE): a European multicentre study from 2010 to 2017. Microorganisms. 2021; 9(7):1420.
Shin A, Tukhanova N, Ndenkeh Jr J, Shapiyeva Z, Yegemberdiyeva R, Yeraliyeva L, et al. Tick‐borne encephalitis virus and West‐Nile fever virus as causes of serous meningitis of unknown origin in Kazakhstan. Zoonoses Public Health. 2021.
Steere A, Strle F, Wormser G, et al. Lyme borreliosis. Nat Rev Dis Primers. 2016; 2:16090. https://doi.org/10.1038/ nrdp.2016.90.
Liebmann N, Sterker I, Sorge I, Opitz S, Merkenschlager A, Gburek-Augustat J. Unusual Localisation of a Borrelia Lym- phocytoma. Klin Monbl Augenheilkd. 2021.
Da Rold G, Obber F, Monne I, Milani A, Ravagnan S, Toniolo F, et al. Clinical tick-borne encephalitis in a roe deer (Cap- reolus capreolus L.). Viruses. 2022;14(2):300.
Salat J, Ruzek D. Tick-borne encephalitis in domestic animals. Acta Virol. 2020;64(2):226-232.
Alfano N, Tagliapietra V, Rosso F, Ziegler U, Arnoldi D, Rizzoli A. Tick-borne encephalitis foci in northeast Italy revealed by combined virus detection in ticks, serosurvey on goats and human cases. Emerg Microbes Infect. 2020;9(1):474-484.
Kriz B, Daniel M, Benes C, Maly M. The role of game (wild boar and roe deer) in the spread of tick-borne encephalitis in the Czech Republic. Vector Borne Zoonotic Dis. 2014;14(11):801-807.
Knap N, Avšič-Županc T. Correlation of TBE incidence with red deer and roe deer abundance in Slovenia. PLoS One. 2013;8(6)
Kellman EM, Offerdahl DK, Melik W, Bloom ME. Viral determinants of virulence in tick-borne flaviviruses. Viruses. 2018;10(6):329.
Jaenson TG, Petersson EH, Jaenson DG, Kindberg J, Pettersson JHO, Hjertqvist M, et al. The importance of wildlife in the ecology and epidemiology of the TBE virus in Sweden: incidence of human TBE correlates with abundance of deer and hares. Parasites Vectors. 2018;11(1):1-18.
Pugliese A, Rosà R. Effect of host populations on the intensity of ticks and the prevalence of tick-borne pathogens: how to interpret the results of deer exclosure experiments. Parasitology. 2008;135(13):1531-1544.
Krbková L, Čapovová I, Homola L, Lindušková J, Salát J, Růžek D. Tick-borne encephalitis in an 8.5-month-old boy sus- pected of febrile seizures. Microorganisms. 2021;9(7):1425.
Kantele A, Rombo L, Vene S, Kundi M, Lindquist L, Erra EO. Three-dose versus four-dose primary schedules for tick-borne encephalitis (TBE) vaccine FSME-immun for those aged 50 years or older: a single-centre, open-label, randomized controlled trial. Vaccine. 2022;40(9):1299-1305.
Panatto D, Domnich A, Amicizia D, Reggio P, Iantomasi R. Vaccination against Tick-Borne Encephalitis (TBE) in Italy: Still a Long Way to Go. Microorganisms. 2022;10(2):464.
Bord S, Dernat S, Ouillon L, René-Martellet M, Vourc’h G, Lesens O, et al. Tick ecology and Lyme borreliosis prevention: a regional survey of pharmacists’ knowledge in Auvergne-Rhône-Alpes, France. Ticks Tick Borne Dis. 2022;13(3):101932.