Features of arterial hypertension in women with menopausal syndrome

Authors

  • Larysa Ivanyvna Kolotvina Odessa National Medical University
  • Halyna Oleksandrivnа Danylchuk Odessa National Medical University
  • Galyna Vasilivna Kornovan Odessa National Medical University
  • Volodymyr Ivanovych Synenko Odessa National Medical University
  • Svitlana Fedorivna Kovalenko Odessa National Medical University
  • Andrii Olexandrovich Kolotvin Odessa National Medical University

DOI:

https://doi.org/10.32782/2415-8127.2023.68.32

Keywords:

arterial hypertension, menopausal syndrome, hot flushes, blood pressure

Abstract

Introduction. The problem of arterial hypertension (AH) in women is especially relevant. The course of hypertension is influenced by many external and internal factors. Today, the menopausal state in women is considered as an important specific risk factor for developing cardiovascular diseases. There is substantial evidence supporting that sex hormones play an important role in regulating blood pressure (BP), demonstrating the prognostic significance of hot flushes in the formation of resistant hypertension and increasing the risk of myocardial infarction and stroke. Materials and methods. We examined 105 women with stage II of AH combined with menopausal syndrome, who made up the main group. The control group consisted of 20 patients with stage II of AH without symptoms of menopausal syndrome. The average age of patients in the main group was 51±1.8 years, the control group was 52±2.4 years. According to the anamnesis, the duration of AH in the examined patients of the main group was 7.8±1.1 years, in patients of the control group – 7.9±1.3 years. All patients were in the menopausal period. The results of the study demonstrate that in women with severe menopausal syndrome, blood pressure figures were on average significantly superior than in patients in the control group, which indicates that menopausal syndrome objectively worsens the course of hypertension during this period. Conclusion. The results of the study indicate that the clinical course of AH in women with menopausal syndrome worsens significantly and depends on the severity of its course.

References

Mishchenko LA, Sokolova LK. Osoblyvosti perebihu ta likuvannia arterialnoi hipertenzii, tsukrovoho diabetu i khronichnoi khvoroby nyrok u stresovykh umovakh voiennoho chasu. Arterialna hipertenziia. 2022; 15 (3–4): 30-38

Zhdan VM, Kitura YeM, Kitura OIe, Babanina MIu, Tkachenko MV. Klinichni pidkhody do terapii arterialnoi hipertenzii u zhinok u period postmenopauzy. Cimeina medytsyna. 2019; 82(2):76-79

Zhuravlova LV, Butova TS. Arterialna hipertenziia u zhinok v period postmenopauzy. Liky Ukrainy.2016; 1(201-202);4-7

Wassertheil-Smoller S, Anderson G, Psaty BM et al. Hypertension and its treat ment in postmenopausal women: baseline data from the Women’s Health Initiative. Hypertension. 2000;36:780-789

Bobrov VO, Davydova IV, Ventsivskyi BM, Zharinov OI. Arterialna hipertenziia u zhinok v period menopauzy: osoblyvosti diahnostyky, dyferentsiiovane likuvannia. Metod. rekomend.Kyiv. 2009; 26.

Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi), tretynnoi (vysokospetsializovanoi) medychnoi dopomohy “Menopauzalni porushennia ta inshi rozlady v perymenopauzalnomu periodi”. Nakaz Ministerstva okhorony zdorov’ia Ukrainy 17 chervnia. Kyiv;№1039;2022,51.

Usategui-Martin R, Perez-Alonso M, et al. Estrogen receptor genes polymorphisms determine serum lipid profile in healthy postmenopausal women treated with calcium, vitamin D, and genistein. J Cell Biochem. 2019; 120: 13115–13120.

Honigberg MC, Zekavat SM, Aragam K, Finneran P, Klarin D, Bhatt DL, et al. Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease. JAMA. 2019;18:10.

Reckelhoff JF. Gender differences in the regulation of blood pressure.Hypertension.2001;37 (5):1199–1208.

Zaichenko HV, Karpenko NO, Stryha OA, Sinitsyna OS. Farmakolohichnyi menedzhment menopauzalnykh rozladiv: fitoestroheny (ohliad literatury). Problemy endokrynnoi patolohii. 2018;4:65-73.

Schoenaker DA, Jackson CA, Rowlands JV, Mishra GD. Socioeconomic position, life style factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents. Int J Epidemiol.2014;43:1542–1562

Schenker J, Sciarra J, Mettler L, Genazzani A, Birkhaeuser M, Eds. Springer: Cham, Switzerland.2018;1:177–189.

Gartoulla P, Bell RJ, Worsley R, Davis SR. Menopausal vasomotor symptoms are associated with poor self-assessed work ability. Maturitas.2016; 87: 33–39.

Bansal, Ramandeep, Aggarwal, Neelam. Menopausal hot flashes: A concise review Journal of Midlife Health. 2019;10:7-19.

Archer DF, Sturdee DW, Baber R, et al. Menopausal hot flushes and night sweats: where are we now?. Climacteric.2011;14:515-528.

Romanova A. Menopauzalna hormonalna terapiia: pokrashchennia menopauzalnykh symptomiv ta perevahy dovhostrokovykh efektiv. Medychni aspekty zdorovia zhinky.2021;1(136):51-58.

Freeman EW, Sammel MD, Sanders RJ. Risk of long-term hot flashes after natural menopause: evidence from the Penn Ovarian Aging Study cohort. Menopause. 2014;21(4): 339-46.

Nappi RE, Simoncini T. Menopause transition: a golden age to prevent cardiovascular disease. Lancet Diabetes Endocrinol.2021;Published Online January 21, 2021. https://doi.org/10.1016/ S22138587(21)000188.

Lee SW, Jo HH, Kim MR, et al. Association between menopausal symptoms and metabolic syndrome in postmenopausal women. Arch Gynecol Obstet.2012; 285:541-548

Lambrinoudaki I, Augoulea A, Armeni E, et al. Menopausal symptoms are associated with subclinical atherosclerosis in healthy recently postmenopausal women. Climacteric,2012;15:350-357

Herber-Gast Gerrie-Cor M, Mishra G D. Early severe vasomotor menopausal symptoms are associated with diabetes. Menopause.2014,21(8): 855-860

Published

2023-10-09

How to Cite

Колотвіна, Л. І., Данильчук, Г. О., Корнован, Г. В., Синенко, В. І., Коваленко, С. Ф., & Колотвін, А. О. (2023). Features of arterial hypertension in women with menopausal syndrome. Scientific Bulletin of the Uzhhorod University. Series «Medicine», (2(68), 191-195. https://doi.org/10.32782/2415-8127.2023.68.32