Mineral density of bone tissue in patients with seronegative spondilitis, resident of transcarthia region

Abstract

Introductions. Disruption of the metabolic processes while seronegative spondyloarthritis develops is accompanied by disorders of metabolism of calcium, phosphor and vitamin D what violates mineral bone density of the lumbar section of the vertebral column and femoral neck. The subject of investigation. Investigations of the mineral density of the bone tissue in the lumbar section of the vertebral column and femoral neck of the patients suffering seronegative spondyloarthritis with reference to their age, gender and X – ray stage of sacroiliitis. Materials and methods applied. Analysis was made of the results of the densitometric examination of the lumbar section of the vertebral columns and femoral neck of 48 patients suffering seronegative spondyloarthritis with reference to their age and gender. All research findings were evaluated in compliance with the recommendation of the World Health Organization and set forth in the per cents. Results of the research and discussion thereof. Pathological changes of the X-ray densometry in the lumbar section of the vertebral column and femoral neck were identified in the 66,7 % of the patients suffering seronegative spondyloarthritis. In particular, 40,6 % patients had the changes developed in both investigated zones, while 59,4 % patients had the changes occurred either in the lumbar section of the vertebral column or in the femur neck. Simultaneously the cases of osteoporosis affected vertebral column and osteopenia developed in femoral neck were identified in 53,8 % of the examined patients. The osteopenia affected both investigated zones was detected in 37,5 % of the patients while 7,7 % of the patients had osteoporosis developed. 53,8 % of the men patients and 72,5 % of the women had the densitogram changes. Up to 60 years old 60 % patients had the mineral bone density changes while over 60 years 84,7 % of the patients endured such changes. The correlation of men and women up to 60 years is 1 : 5 while over 60 years 1 : 2,5. Up to 60 years old the changes of one investigated zone with signs of osteopenia (70,6 %) dominated while over 60 years both zones have developed signes of osteoporosis (50 %). The X-ray investigation detects signs of sacroiliitis affected all petients who had undergone investigation: two-sided of the II stage – 21,9 %, one sided – IV stage – 8,1 % and two – sided of III – IV stage/ 70 %. 71,9 % of the patients had detected osteopenia, 6,2 % had detected ostheoporosis, 21,9 % patients had femoral neck ostheopenia combined with osteoporosis of the lumbar section of the vertebral column. Osteopenia dominated among the patients suffering 1st and 2nd X-ray stage of sacroiliitis while osteoporisis and combination of the osteopenia of femoral neck with ostheoporosis of the lumbar section of the vertebral column (L1 – L4) of IV stage. Conclusion. Disorder of the mineral density of the bone tissue was detected in 66,7 % of the patients suffering seronegative spondyloathritis. Frequency changes dominated among women (72,5 %). The changes of mineral density of the bone tissue of the patients suffering seronegative spondyloathritis who live in Zakarpatska province manifested mostly in combination of ostheoporosis of the lumbar section of the vertebral spine with osteopenia of femoral neck.