Передумови для виникнення себорейного дерматиту
Ключові слова:
Malassezia spp., seborrheic dermatitis, sebaceous gland.Анотація
Вступ. Себорейний дерматит (СД) часто асоціюють з присутністю на шкірі гибів роду Malassezia. Будучи частиною мікробіому M. restricta, M. furfur, M. globosa захищають від впливу УФ-випромінювання та патогенних бактерій та колонізують практично всі ділянки шкіри, крім долонь та стоп. Надмірна секреція шкірного сала, запалення та свербіж, які прийнято вважати основними симптомами СД, частіше за все спричинені нейро-, ендокринними, імунними та психічними розладами. Неможливо точно встановити причину запалення шкіри у ділянках з великою кількістю сальних залоз. Тому сучасне лікування пацієнтів з себорейним дерматитом повинно мати персоналізований та предиктивний підхід і враховувати фенотип шкіри, соматичні та психічні коморбідні розлади. Метою дослідження було встановити фактори, які створюють передумови для виникнення себорейного дерматиту та надмірного росту Malassezia spp. Матеріали та методи: аналіз оригінальних досліджень з бібліотек Wiley online library, Cochrane library, Medline. Висновки. Себорейний дерматит варто розглядати як прояви маніфестації чи єдині видимі симптоми деяких соматичних та психічних захворювань. Колонізація запалених ділянок шкіри грибами Malassezia spp. є наслідком адаптації гриба до нових умов існування, а не причиною виникнення себорейного дерматита.
Посилання
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