Biopsychosocial model of treatment of functional dyspepsia: the modern role of the medical psychologist according to the Rome V criteria
DOI:
https://doi.org/10.32782/2415-8127.2026.74.21Keywords:
functional dyspepsia, functional gastrointestinal disorders, disorders of gut-brain interaction, biopsychosocial model, medical psychologist, Rome Criteria VAbstract
More than two millennia ago, Hippocrates stated: “It is far more important to know what sort of person has a disease than what disease a person has.” Although this statement long predates the era of evidence-based medicine, it remarkably reflects the philosophy of patientcentered care. Today, this concept has gained a solid scientific foundation through the biopsychosocial model and the concept of Disorders of Gut–Brain Interaction (DGBI), which constitute the conceptual basis of the Rome V criteria. This paradigm recognizes the need for multidisciplinary patient management and provides the rationale for integrating the medical psychologist as an essential member of the multidisciplinary team. To analyze the role of the medical psychologist in the multidisciplinary management of patients with functional dyspepsia, a gastroduodenal disorder of gut–brain interaction, in accordance with the Rome V criteria conceptual framework, and to highlight the importance of the biopsychosocial model, psychological phenotyping, assessment of psychosocial factors, and psychological interventions in implementing patient-centered care. Contemporary management of functional dyspepsia should include not only pharmacological treatment and dietary recommendations but also evidence-based psychological interventions, including cognitive behavioral therapy, psychoeducation, stress management strategies, and mindfulness-based interventions. Such an integrated approach provides more comprehensive and sustainable clinical outcomes and forms the basis of personalized, patient-centered care, in which the medical psychologist is not merely an additional consultant but an integral member of the multidisciplinary team. Integration of the medical psychologist into the multidisciplinary team managing patients with Disorders of Gut–Brain Interaction facilitates the early identification of psychosocial factors contributing to symptom persistence, improves the effectiveness of comprehensive treatment, enhances treatment adherence, reduces unnecessary healthcare utilization and inappropriate diagnostic procedures, and ultimately improves patient’s prognosis and quality of life.
References
Flamm SL, Fontana RJ, Karvellas CJ, Fix OK, Wasan SK, Singh S, et al. AGA Clinical Practice Guideline on the Evaluation and Management of Acute Liver Failure. Gastroenterology. 2026;170(4):1145-1162. Available from: https://www.gastrojournal.org/article/S0016-5085(26)00145-9/fulltext
Black CJ, Paine PA, Agrawal A, Aziz I, Eugenicos MP, Houghton LA, et al. British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut. 2022;71(9):1697-1723. Available from: https://gut.bmj.com/content/71/9/1697
Corsetti M, Shin A, Lacy BE, Cash BD, Simrén M, Schmulson MJ, et al. Bowel disorders. Gastroenterology. 2026;170(6):1261-1282. doi:10.1053/j.gastro.2026.02.003.
Engel GL. The need for a new medical model: a challenge for biomedicine. Science. 1977;196(4286):129-136. doi:10.1126/science.847460.
Bolton D. A revitalized biopsychosocial model: core theory, research paradigms, and clinical implications. Psychol Med. 2023;53(16):7504-7511. doi:10.1017/S0033291723002660
Drossman DA, Chang L, Tack J. Disorders of Gut-Brain Interaction and the Rome V Process. Gastroenterology. 2026;170(6):1083-1098. doi:10.1053/j.gastro.2026.02.014.
Mozhyna TL. Kliuchovi zminy v Rymskykh kryteriiakh V (2026): vid onovlenoi kontseptsii do novykh nozolohii ta diahnostychnykh kryteriiv [Key changes in Rome V criteria (2026): from the updated concept to new nosologies and diagnostic criteria]. Zdorovia Ukrainy 21 Storichchia. 2026;(9). Available from: health-ua.com
Törnblom H., Carbone F., Hasler W. L., Smout A., Suzuki H., Tack J., Talley N. J., Stanghellini V. Gastroduodenal Disorders. Gastroenterology, 2026 May; 170 (6): 1240-1260. doi: 10.1053/j.gastro.2026.01.038
Van Oudenhove L, Levy RL, Crowell MD, Drossman DA, Halpert AD, Keefer L, et al. Biopsychosocial Aspects of Functional Gastrointestinal Disorders: How Central and Environmental Processes Contribute to the Development and Expression of Functional Gastrointestinal Disorders. Gastroenterology. 2016;150(6):1355–1367.e2. doi:10.1053/j.gastro.2016.02.027
Wei Z, Xing X, Tantai X, Xiao C, Yang Q, Jiang X, et al. The Effects of Psychological Interventions on Symptoms and Psychology of Functional Dyspepsia: A Systematic Review and Meta-Analysis. Front Psychol. 2022;13:827220. doi:10.3389/fpsyg.2022.827220.
Khasawneh M, Mokhtare M, Moayyedi P, Black CJ, Ford AC. Efficacy of gut-brain neuromodulators in irritable bowel syndrome: an updated systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2025;10(6):537-549. doi:10.1016/S2468-1253(25)00051-2.
Khasawneh M, Thakur ER, Goodoory VC, Moayyedi P, Black CJ, Ford AC. Efficacy of gut-brain neuromodulators and brain-gut behaviour therapies for irritable bowel syndrome: systematic review and network meta-analysis. Gut. 2026 Jun 26. doi:10.1136/gutjnl-2026-339311
Hanna-Jairala I, Drossman DA. Central neuromodulators in irritable bowel syndrome: why, how, and when. Am J Gastroenterol. 2024;119(7):1272-1284. doi:10.14309/ajg.0000000000002800.
Temido MJ, Cristiano M, Gouveia C, Mesquita B, Figueiredo P, Portela F. Antidepressants in irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Ann Gastroenterol. 2025;38(3):284-293. doi:10.20524/aog.2025.0962.
Drossman DA, Tack J, Ford AC, Szigethy E, Törnblom H, Van Oudenhove L. Neuromodulators for functional gastrointestinal disorders (disorders of gut-brain interaction): a Rome Foundation working team report. Gastroenterology. 2018;154(4):1140-1171.e1. doi:10.1053/j.gastro.2017.11.279.
Fadgyas Stanculete M, Dumitrascu DL, Drossman D. Neuromodulators in the brain-gut axis: their role in the therapy of the irritable bowel syndrome. J Gastrointestin Liver Dis. 2021;30(4):517-525. doi:10.15403/jgld-4090.





