Chronic lacunar tonsillitis: impact on the associative microbiome of the oral cavity and individual indicators of anti-infective protection
DOI:
https://doi.org/10.32782/2415-8127.2026.73.13Keywords:
oral cavity, microbiome, chronic lacunar anginaAbstract
Chronic lacunar tonsillitis is a chronic infectious-inflammatory process localized in the palatine tonsils and characterized by the presence of purulent plaques (abscesses) in the lacunae (depressions) of the tonsils, as well as their enlargement and edema. The human microbiota is functionally associated with numerous infectious-inflammatory diseases, but only a small number of studies concern changes in the tonsil microbiota, in particular in the development of chronic angina and its impact on the oral microbiome.
Objective. To investigate the taxonomic composition of the oral microbiota in chronic lacunar tonsillitis, to assess the microecological indicators of each taxon and to determine the relationship of the microbiota with the patient's body, their impact on individual indicators of anti-infective immunity and the functioning of the "macroorganism-microbiome" ecosystem.
Clinical material from 148 patients of early working age (15-35 years) they studied, of which 111 we diagnosed with chronic lacunar angina. Microbiological examination of oral fluid of patients and practically healthy volunteers we carried out using classical methods.
It we established that the main oropharyngeal microbiome of practically healthy people of early working age is represented by autochthonous S. salivarius and bacteria of the genus Lactobacillus, and the additional one is S. sanguis, S. lactis, N. lactamica, while in patients with chronic lacunar angina, mainly S. aureus and S. pyogenes are detected. Accordingly, this indicates the destabilization of the oropharyngeal microbiome in chronic lacunar angina, and its course creates different conditions for microorganisms - from optimal to negative.
According to the results obtained the development of chronic lacunar angina in people of early working age (15-35 years) leads to destabilization of the taxonomic composition of the oropharyngeal microbiome with the elimination of autochthonous bacteria and its contamination of the oropharynx with opportunistic bacteria and yeast-like fungi of the genus Candida.
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