Changes in the colon microbiocenosis in patients with non-alcoholic fatty liver disease with TORCH infection
DOI:
https://doi.org/10.32782/2415-8127.2023.67.8Keywords:
non-alcoholic fatty liver disease, TORCH-infection, colon dysbiosis.Abstract
Introduction. The results of recent studies investigate the relationship between the formation of metabolic disorders in the body, including non-alcoholic fatty liver disease (NAFLD), and the intestinal microbiocenosis disorder, especially in patients with TORCH infection. The purpose of the study: to investigate the peculiarities of changes in the quantitative and qualitative composition of the colon microflora in patients with NAFLD infected with TORCH infection. Object and research methods. There were examined 72 patients with NAFLD. The patients were divided into two groups: the first group was included the patients with NAFLD who have detected antibodies of the IgG class to TORCH infections group (n=40); The II group was consisted of patients on NAFLD, who has had the test negative for infections of the TORCH group (n=32). All examined patients were undertaken general clinical examinations, as well as determination of the state of the quantitative and qualitative composition of the colon microflora. Research results and their discussion. Analysis results of biochemical blood analysis shows strongly marked detection of syndromes of cytolysis and cholestasis in NAFLD patients infected with pathogens of the TORCH group. The results of the anthropometric study indicate an inaccurate measure of the body mass index (BMI) in the vast majority of examined patients with NAFLD of both groups. At the same time, excess body weight is diagnosed more often in patients with NAFLD infected with pathogens of the TORCH group, while obesity of Class I and II is identified in patients of the II group. Analyzing the degree of severity of dysbiotic changes in patients of the I group the degree of dysbiosis (Ddys) II and III was diagnosed mainly in 47.% and in 30.0% of patients accordingly and dysbiosis of the IV degree was determined in 7.5% of patients, while in the II group patients dysbiosis of the II and I degrees mainly Conclusions. 1. Mainly dysbiosis of the II and III degrees was determined in NAFLD patients infected with pathogens of the TORCH group 47.5% and 30.0% of the examined respectively. 2. A direct dependancy between the severity of cholestatic and cytolytic syndromes and dysbiosis of the II degree in patients with NAFLD infected with pathogens of the TORCH group (r= 0.86; p<0.01 and r= 0.74; p<0, 05 respectively) was identified.
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