The impact of metabolic disorders on ageing rates in patients with moderate cardiovascular risk
DOI:
https://doi.org/10.32782/2415-8127.2022.66.10Keywords:
overweight, obesity, biological age, accelerated ageing, telomere length.Abstract
Introduction. Prediction of cardiovascular risk (CVR) and the effectiveness of prevention of metabolic-associated diseases (MAD) is a serious challenge of modern medicine. Recently, for this purpose, it has been proposed to estimate the biological age (BA) of a person for the timely determination of premature aging. Calendar age (CA) is an important risk factor for the development of age-related diseases, including cardiovascular disease (CVD). Biological age (BA) may be more accurate for assessing CVR and predicting early vascular ageing and the development of atherosclerosis. The available data allow us to testify about the relationship between premature aging and the most significant pathogenetic factors of MAD. Purpose: to assess the impact of metabolic disorders on biological age in patients with moderate cardiovascular risk and the significance for the development of premature ageing. Materials and methods. 120 patients with moderate CVR (by SCORE) aged from 32 to 59 years (women n=65, 54.17%) were involved in the examination. They were divided into the main group (n= 67) who additionally had metabolic disorders (overweight/obesity, insulin resistance, dyslipidemia) and a comparison group (n=53) without metabolic disorders. All included patients underwent anthropometric studies with calculation of body mass index (BMI), studies of indicators of carbohydrate metabolism and lipid metabolism. Determination of biological age was carried out according to the methods of A.G. Gorelkin and B.B. Pinkhasov and P.V. Voytenko. Telomere length (TL) of blood leukocytes and buccal epithelium was determined by real-time PCR. Statistical data processing was performed using the Statistica program package, version 10.0. Results and discussion. The BA of normal-weight patients not only did not exceed the CA, but was also lower in both the main group and the comparison group. At the same time, in the overweight patients BA did not differ from CA in both groups, and the presence of obesity led to an acceleration of the rate of ageing in patients of the main group. It was determined that an increase in BMI and waist circumference (WC), hyperinsulinemia, hyperuricemia, and high levels of proatherogenic lipids are associated with an increase in BA regardless of the presence of metabolic disorders and may influence the ageing rate. Also, the presence of overweight and obesity is associated with a decrease in TL and an increase in BA. Conclusions. Assessment of premature ageing allows to identify persons with a high risk of developing age-related diseases at a time when there are no clinical symptoms yet, and to develop measures for timely and effective prevention.
References
Adeva-Andany MM, Martínez-Rodríguez J, González-Lucán M, Fernández-Fernández C, Castro-Quintela E. Insulin resistance is a cardiovascular risk factor in humans. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019;13(2):1449-55. doi:10.1016/j.dsx.2019.02.023
Ageing and health. World Health Organization, 05 Feb 2018. https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.
Assmann KE, Ruhunuhewa I, Adjibade M, Li Z, Varraso R, Hercberg S, Galan P, Kesse-Guyot E. The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging. Nutrients. 2018 Apr 20;10(4):515. doi: 10.3390/nu10040515. PMID: 29677164; PMCID: PMC5946300.
Balayah Z, Alsheikh-Ali AA, Rashed W, Almahmeed W, Mulla AA, Alrawahi N, Mora S, Dugani SB, Zubaid M. Association of obesity indices with in-hospital and 1-year mortality following acute coronary syndrome. Int J Obes (Lond). 2021 Feb;45(2):358-368. doi: 10.1038/s41366-020-00679-0. Epub 2020 Sep 17. PMID: 32943761.
Belikov AV. Age-related diseases as vicious cycles. Ageing Res Rev. 2019 Jan;49:11-26. doi: 10.1016/j.arr.2018.11.002. Epub 2018 Nov 17. PMID: 30458244.
Buttet M, Bagheri R, Ugbolue UC, Laporte C, Trousselard M, Benson A, Bouillon-Minois JB, Dutheil F. Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis. Mech Ageing Dev. 2022 Sep;206:111694. doi: 10.1016/j.mad.2022.111694. Epub 2022 Jun 26. PMID: 35760212.
Conte M, Martucci M, Sandri M, Franceschi C, Salvioli S. The Dual Role of the Pervasive "Fattish" Tissue Remodeling With Age. Front Endocrinol (Lausanne). 2019 Feb 26;10:114. doi: 10.3389/fendo.2019.00114. PMID: 30863366; PMCID: PMC6400104.
Csige I, Ujvárosy D, Szabó Z, Lőrincz I, Paragh G, Harangi M, Somodi S. The Impact of Obesity on the Cardiovascular System. J Diabetes Res. 2018 Nov 4;2018:3407306. doi: 10.1155/2018/3407306. PMID: 30525052; PMCID: PMC6247580.
Diebel LWM, Rockwood K. Determination of Biological Age: Geriatric Assessment vs Biological Biomarkers. Curr Oncol Rep. 2021 Jul 16;23(9):104. doi: 10.1007/s11912-021-01097-9. PMID: 34269912; PMCID: PMC8284182.
Field AE, Robertson NA, Wang T, Havas A, Ideker T, Adams PD. DNA Methylation Clocks in Aging: Categories, Causes, and Consequences. Mol Cell. 2018 Sep 20;71(6):882-895. doi: 10.1016/j.molcel.2018.08.008. PMID: 30241605; PMCID: PMC6520108..
Global strategy and action plan on ageing and health. World Health Organization, 2017. 56 pp. ISBN 978-92-4-151350-0 ;
Grover, S.A., Kaouache, M., Rempel, P., et al., 2015. Years of life lost and healthy lifeyears lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study. Lancet Diabetes Endocrinol. 3, 114–122. https://doi. org/10.1016/S2213-8587(14)70229-3
Guerville F, De Souto Barreto P, Ader I, Andrieu S, Casteilla L, Dray C, Fazilleau N, Guyonnet S, Langin D, Liblau R, Parini A. Revisiting the hallmarks of aging to identify markers of biological age. The Journal of prevention of Alzheimer’s disease. 2020;7(1):56-64. Doi:10.14283/jpad.2019.50
Hamczyk MR, Nevado RM, Barettino A, Fuster V, Andres V. Biological versus chronological aging: JACC focus seminar. Journal of the American College of Cardiology. 2020;75(8):919-30. Available at: https://www.jacc.org/doi/full/10.1016/j. jacc.2019.11.062
Hill MA, Yang Y, Zhang L, Sun Z, Jia G, Parrish AR, Sowers JR. Insulin resistance, cardiovascular stiffening and cardiovascular disease. Metabolism. 2021;119:154766. doi:10.1016/j.metabol.2021.154766
Jansen R, Han LK, Verhoeven JE, Aberg KA, van den Oord EC, Milaneschi Y, Penninx BW. An integrative study of five biological clocks in somatic and mental health. Elife. 2021 Feb 9;10:e59479. doi: 10.7554/eLife.59479. PMID: 33558008; PMCID: PMC7872513.
Kolesnikova OV, Potapenko AV, Vysotska OV, Zaprovalna O. Evaluation of hormonal and metabolic parameters, along with cardiovascular risk factors in women with non-alcoholic fatty liver disease combined with subclinical hypothyroidism depending on age. Eureka: Health Sciences. 2021 Vol 1. P 48-57. doi:10.21303/2504-5679.2021.001618
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414. PMID: 29676998; PMCID: PMC5940111.
Lin YH, Chiou JM, Chen TF, Lai LC, Chen JH, Chen YC. The association between metabolic syndrome and successful aging- using an extended definition of successful aging. PLoS One. 2021 Nov 30;16(11):e0260550. doi: 10.1371/journal. pone.0260550. PMID: 34847175; PMCID: PMC8631634.
Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY). 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684. PMID: 30669119; PMCID: PMC6366976.
Matthew CL Phillips. Metabolic Strategies in Healthcare: A New Era. Aging and disease. 2022, 13(3): 655-672 https://doi.org/10.14336/AD.2021.1018
Morgan E., Ake T. Lu, Austin Quach, Brian H. Chen, Themistocles L. Assimes, Stefania Bandinelli, Lifang Hou, An epigenetic biomarker of aging for lifespan and healthspan Aging 10, no. 4 (April 2018): 573–91. https://doi.org/10.18632/ aging.101414.
Riaz H, Khan MS, Siddiqi TJ, Usman MS, Shah N, Goyal A, Khan SS, Mookadam F, Krasuski RA, Ahmed H. Association Between Obesity and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Mendelian Randomization Studies. JAMA Netw Open. 2018 Nov 2;1(7):e183788. doi: 10.1001/jamanetworkopen.2018.3788. PMID: 30646365; PMCID: PMC6324374.
Rollandi GA, Chiesa A, Sacchi N, Castagnetta M, Puntoni M, Amaro A, Banelli B, Pfeffer U. Biological age versus chronological age in the prevention of age associated diseases. OBM Geriatrics. 2019;3(2):14. Doi:10.21926/obm.geriatr.1902051
Salameh Y, Bejaoui Y, El Hajj N. DNA Methylation Biomarkers in Aging and Age-Related Diseases. Front Genet. 2020 Mar 10;11:171. doi: 10.3389/fgene.2020.00171. PMID: 32211026; PMCID: PMC7076122.
Salmon A. Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process? Antioxidants [Internet]. MDPI AG; 2016 Jul 18;5(3):24. Available from: http://dx.doi.org/10.3390/antiox5030024
Salvestrini V, Sell C, Lorenzini A. Obesity May Accelerate the Aging Process. Front Endocrinol (Lausanne). 2019 May 3;10:266. doi: 10.3389/fendo.2019.00266. PMID: 31130916; PMCID: PMC6509231.
Santos AL, Sanchari Sinha S. Obesity and aging: Molecular mechanisms and therapeutic approaches. Ageing Research Reviews. 2021 Vol.67; e101268, https://doi.org/10.1016/j.arr.2021.101268. https://www.sciencedirect.com/science/article/pii/ S1568163721000155
Stout MB, Justice JN, Nicklas BJ et al. Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda). 2017 Jan;32(1):9-19. doi: 10.1152/physiol.00012.2016. PMID: 27927801; PMCID: PMC5338596.
Zgheib NK, Sleiman F, Nasreddine L, Nasrallah M, Nakhoul N, Isma’eel H, Tamim H. Short Telomere Length is Associated with Aging, Central Obesity, Poor Sleep and Hypertension in Lebanese Individuals. Aging Dis. 2018 Feb 1;9(1):77-89. doi: 10.14336/AD.2017.0310. PMID: 29392083; PMCID: PMC5772860.
