Characteristics of endothelial dysfunction in patients with atopic dermatitis
DOI:
https://doi.org/10.32782/2415-8127.2022.66.8Keywords:
vascular endothelial growth factor, vascular cell adhesion molecule1, atopic dermatitis.Abstract
Introduction. Skin lesions in atopic dermatitis (AD) are apparently associated with vascular changes, as blood vessels provide pathways for the transport of immune cells. The aim of the study: study of the state of endothelial dysfunction in patients with atopic dermatitis. Materials and methods. 70 patients with AD were examined. Groups were formed depending on the SСORAD index (I subgroup – with SСORAD index up to 20 points, II – with SСORAD index 20-40 points, III subgroup – with SСORAD index from 40 and above points). Indicators of endothelial dysfunction of VEGF and VCAM-1 in blood serum were determined by the immunoenzymatic method. Research results and their discussion. A significant percentage of deviations from the reference interval of both the level of VEGF (52 (74.3%) examined) and VCAM-1 (32 (45.7%) examined) in blood serum among AD patients was established. There were 4.6 times more people of the III subgroup with an elevated level of VEGF in blood serum than patients with a reference value (p˂0.001) and 1.52 times more than among patients of the I subgroup (p=0.0121). Among the patients of the I, only the reference values of the vascular cell adhesion molecule-1 were found. Among individuals of the III subgroup with an elevated level of VCAM-1 was 1.9 times more than with its reference value (p=0.016). It was established that the level of VEGF in blood serum in patients of the III was 1.4 times higher compared to the level in patients of the II and 1.68 times higher than in patients of the I. Similar changes were found in the level of VCAM-1 in blood serum in AD patients. The highest level of VCAM-1 was found in patients of the III subgroup, which was 2.2 times higher than that in the II and 5.4 times in the I subgroups. In patients with AD with a minimum duration of the disease (1 year), the level of VEGF in blood serum was within the reference values. Probably the highest value of this indicator was noted in patients with a long course of the disease (16 and more years), (р˂0.05). Conclusions. A feature of atopic dermatitis is the development of endothelial dysfunction, namely due to an increase in the level of endothelial vasoactive factors VEGF, VCAM-1 (p<0.01). Violation of endothelial function in AD correlates with the severity of the disease (p<0.05). The increase in VEGF content is associated with the duration of AD (p<0.05).
References
Mastraftsi S, Vrioni G, Bakakis M, Nicolaidou E, Rigopoulos D, Stratigos AJ, Gregoriou S. Atopic Dermatitis: Striving for Reliable Biomarkers. J. Clin. Med. 2022 11: 4639. https://doi.org/10.3390/jcm11164639
Ziehfreund S, Tizek L, Hangel N, Fritzsche M, Weidinger S. et al. Requirements and expectations of high-quality biomarkers for atopic dermatitis and psoriasis in 2021—A two-round Delphi survey among international experts. J. Eur. Acad. Dermatol. Venereol. 2022; 36: 1467-1476.
Gallegos-Alcalá P, Jiménez M, Cervantes-García D, Salinas E. The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis. Int J Mol Sci. 2021; 22(19): 10661 doi: 10.3390/ijms221910661
Krajina I, Stupin A, Šola M, Mihalj M. Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris. Antioxidants (Basel). 2022; 11(7): 1269. doi: 10.3390/antiox11071269
Hanusch B, Sinningen K, Brinkmann F, Dillenhöfer S, Frank M, Jöckel KH, et. all. Characterization of the L-Arginine/ Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases. Int. J. Mol. Sci. 2022; 23(4): 2136. https://doi.org/10.3390/ijms23042136
Lee HJ, Hong YJ, Kim M. Angiogenesis in Chronic Inflammatory Skin Disorders J. Mol. Sci. 2021; 22, 12035. https://doi.org/10.3390/ijms222112035
Luengas-Martinez A, Paus R, Helen S. Antivascular endothelial growth factor-A therapy: a novel personalized treatment approach for psoriasis. Young iBritish Journal of Dermatology. 2022; 186, 782–791.
McAleer MA, Jakasa I, Hurault G, Sarvari P, McLean WHI, Tanaka iD RJ et all. Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell-related immunity and angiogenesis. British Journal of Dermatology. 2019; 180, 586–596.
Bocheva GSt, Slominski RM, Slominski AT. Immunological Aspects of Skin Aging in Atopic Dermatitis. Int. J. Mol. Sci. 2021; 22, 5729. https://doi.org/10.3390/ijms22115729
Liu X, Michael S, Bharti K, Ferrer M, Song MJ. A Biofabricated Vascularized Skin Model of Atopic Dermatitis for Preclinical Studies. Biofabrication. 2020; 12(3): 035002. doi:10.1088/1758-5090/ab76a1.
Zhao JW, Ping JD, Wang YF, Liu XN, Li N, Hu ZL, Ming L. Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K/Akt/p38 MAPK/HIF-1 pathway in chronic spontaneous urticaria. Clin. Immunol. 2020; 215, 108444. doi: 10.1016/j.clim.2020.108444
