Probability of an epileptic attack in patients with supratentorial meningiomas of the brain

Abstract

Introduction: Meningioma is the most common intracranial tumor in adults. From one third to half of patients with brain tumors, the first clinical syndrome of the disease has epileptic seizures. Seizures significantly reduce the quality of life of patients. Identifying factors that influence the development of the seizures can affect the tactics of conducting patients without seizure. Aim: Identify possible predictors of the development of epileptic seizures in patients with supratentorial mening iomas. Materials and methods: A retrospective analysis of the prevalence of epileptic seizures in 242 patients with totally removed supratentorial meningioma of the brain was conducted. The connection between different clinical-instrumental parameters and seizures was investigated. Results: The proportion of men among patients with seizures was 36%, and in the group of patients without seizures 30.3%, p = 0.08. In 2 out of 13 patients with a megigiomas of saddle, epileptic seizures were observed, this localization was significantly less associated with convulsions p <0.05. The average size of the tumor in the general group was 41.3 ± 16.0 mm. In the group of patients without seizures, 41.1 ± 15.5 mm, and in the group with seizures 46.7 ± 16.5 - p = 0.01. In general, the histology groups do not differ significantly. However, in the analysis of histological subgroups revealed that meningioma with psammomatous bodies is significantly more common in patients with seizures p <0.01 Conclusions: There is a tendency to a greater frequency of attacks in men with meningiomas, and to a lower frequency of attacks in patients with anaplastic meningiomas. The presence of seizure is associated with a significantly higher mean tumor size. For psammomatous meningiomas a greater frequency of epileptic seizures is characteristic.