Comorbidity of chronic obstructive pulmonary disease and hypertension: the relationship between oxidative stress and respiratory function
DOI:
https://doi.org/10.32782/2415-8127.2022.65.5Keywords:
chronic obstructive pulmonary disease, hypertension, comorbidity, oxidative stress, spirometry.Abstract
Introduction. Hypertension (AH) is considered to be one of the major comorbidities associated with chronic obstructive pulmonary disease (COPD). The pathogenesis of COPD, like hypertension, is closely related to oxidative stress. The question of the influence of the changes developing against the background of the studied comorbidity on the indicators of the function of external respiration remains important. The aim of this study – to establish the relationship between the indicators of free radical oxidation and the function of external respiration in the combined course of chronic obstructive pulmonary disease and hypertension. Materials and methods. The study included 53 patients with COPD, 28 of whom had comorbid hypertension, stage 1. Spirography was performed on a Spirolab III (Germany). DCFH-DA (dichlorodihydrofluorescein diacetate), a specific test for the detection of hydrogen peroxide (H2O2), and DHE (dichloroetidium), which detects anion-radical superoxide (O2 • -), were determined on a flow cytometer USICman X EP. Serum 8-isoprostane levels were measured by enzyme-linked immunosorbent assay. Research results and their discussion. In patients with COPD, as well as with the comorbidity of COPD + hypertension, a relationship was found between the expression of oxidative stress and indicators of respiratory function. Thus, in patients of both study groups, high values of H2O2, O2•- and 8-isoprostane were significantly associated with low spirographic values, which indicated bronchial obstruction. The indicators of oxidative stress were statistically significantly inversely correlated with the values that characterize the patency of the large and medium bronchi (MOS 25 and MOS 50). Conclusions. In patients with a combined course of COPD and hypertension, there was a relationship between the expression of oxidative stress and indicators of respiratory function, which was characterized by the association of high values of free radical oxidation with low spirographic indicators (hydrogen peroxide-FEV1 = -0.55; O2•- -FEV1 = 0.33; 8-isoprostane-FEV1 = -0.51), which indicate bronchial obstruction.
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